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BioGaia
Reuteri®—A truly Human Probiotic
Adults, Children, Expectant Moms & Infants

BioGaia Chewable Tablets
BioGaia Straws
BioGaia Drops

 
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Origin of BioGaia’s Reuteri®: The commercial strain of Reuteri® (a lactic acid bacterium) for human use known as Lactobacillus reuteri Protectis or ATCC 55730 was isolated from the breast milk of a woman living in the Peruvian Andes—someone living in perfect harmony with nature. The fact that Reuteri occurs naturally in humans makes it truly a human probiotic.* It is one of very few species of lactobacilli that is uniquely adapted to reside in the gastrointestinal (GI) tract of man.* Most species have their natural living environment outside the human body and are therefore just temporary residents derived from food.*

References: 1. (2001) The Food and Agriculture Organization of the United Nations and the World Health Organization Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria. Food and Agriculture Organization, World Health Organization, Report No. 10-1-2001.
2. Walker, W.A., et al. (1999) Protective Nutrients for the Immature Gut. In Ziegler, E. and Moro, G. (eds.), Nutrition of the Very Low Birthweight Infant. Lippincott William and Wilkins, Philadelphia, PA, pp. 179-197.
3. Isolauri, E., et al. (2004) Microbial-Gut Interactions in Health and Disease. Probiotics. Best Pract Res Clin Gastroenterol, 18, 299-313.
4. O'Hara, A.M., et al. (2007) Gut Microbiota: Mining for Therapeutic Potential. Clin Gastroenterol Hepatol, 5, 274-84.
5. Charrois, T.L., et al. (2006) Probiotics. Pediatr Rev, 27, 137-9.
6. Wenus, C., et al. (2007) Prevention of Antibiotic-Associated Diarrhoea by a Fermented Probiotic Milk Drink. Eur J Clin Nutr.
7. Sinkiewicz, G., et al. (2005) Occurence of Lactobacillus Reuteri, Lactobacilli and Bifidobacteria in Human Breast Milk. Pediatr Res, 58, Abstract 353.
8. Reuter, G. (2001) The Lactobacillus and Bifidobacterium Microflora of the Human Intestine: Composition and Succession. Curr Issues Intest Microbiol, 2, 43-53.
9. Abrahamsson, T., et al. (2005) Intestinal Microbiota in Infants Supplemented with the Probiotic Bacterium Lactobacillus Reuteri. J Pediatr Gastroenterol Nutr, 40, PN1-17.
10. Romeo, M.G., et al. (2006) The Role of Probiotics in the Prevention of Bacterial and Candida Infections in Neonatal Intensive Care. Prospective Study with Control Group. J Perinat Med, 34, A9, abstract MSL24.
11. Weizman, Z., et al. (2005) Effect of a Probiotic Infant Formula on Infections in Child Care Centers: Comparison of Two Probiotic Agents. Pediatrics, 115, 5-9.
12. Ruiz-Palacios, G., et al. (1996) Feeding of a Probiotic for the Prevention of Community-Acquired Diarrhea in Young Mexican Children. Pediatr Res, 39, Part 2: 184A Abstract 1089.
13. Guerrero, M.L., et al. (1996) Effect of Probiotic-Containing Beverages on Incidence of Diarrhoea. 1st World Congress of Pediatric Infectious Diseases, Acapulco, Mexico.
14. Savino, F., et al. (2007) Lactobacillus Reuteri (American Type Culture Collection Strain 55730) Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Study. Pediatrics, 119, e124-30.
15. Lionetti, E., et al. (2006) Lactobacillus Reuteri Therapy to Reduce Side-Effects During Anti-Helicobacter Pylori Treatment in Children: A Randomized Placebo Controlled Trial. Aliment Pharmacol Ther, 24, 1461-8.
16. Eom, T.H., et al. (2005) The Therapeutic Effect of Lactobacillus Reuteri in Acute Diarrhea in Infants and Toddlers. Korean J Ped, 48, 986-9.
17. Shornikova, A.V., et al. (1997) Lactobacillus Reuteri as a Therapeutic Agent in Acute Diarrhea in Young Children. J Pediatr Gastroenterol Nutr, 24, 399-404.
18. Shornikova, A.V., et al. (1997) Bacteriotherapy with Lactobacillus Reuteri in Rotavirus Gastroenteritis. Pediatr Infect Dis J, 16, 1103-7.
19. Cirillo, A., et al. (2005) Effectiveness of L. Reuteri in Patients with Atopic Dermatitis and Cow Milk Intolerance. Preliminary Study. Italian Society for Clinical Allergy and Immunology Congress, Rome, Italy.
20. Weizman, Z., et al. (2006) Safety and Tolerance of a Probiotic Formula in Early Infancy Comparing Two Probiotic Agents: A Pilot Study. J Am Coll Nutr, 25, 415-9.
21. Connolly, E., et al. (2005) Safety of D(-)-Lactic Acid Producing Bacteria in the Human Infant. J Pediatr Gastroenterol Nutr, 41, 489-92.
22. Karvonen, A., et al. (2001) Safety and Possible Antidiarrhoel Effect of the Probiotic Lactobaciullus Reuteri after Oral Administration to Neonates. Clin Nutr, 20, 63 abstract 216.
23. Ruiz-Palacios, G., et al. (1996) Tolerance and Fecal Colonization with Lactobacillus Reuteri in Children Fed a Beverage with a Mixture of Lactobacillus Sp. Pediatr Res, 39, 104A.
24. Jakobsson, T., et al. (2005) The Effect of Oral Supplementation of Lactobacillus Reuteri on the Immunologic Composition of Breast Milk. J Pediatr Gastroenterol Nutr, 40, 624.
25. Valeur, N., et al. (2004) Colonization and Immunomodulation by Lactobacillus Reuteri ATCC 55730 in the Human Gastrointestinal Tract. Appl Environ Microbiol, 70, 1176-81.
26. Bjorkman, P. (1999) Colonization of the Human Gastrointestinal Tract by the Lactic Acid Bacteria Lactobacillus Reuteri. Department of Food Technology. University of Helsinki, Finland.
27. Tubelius, P., et al. (2005) Increasing Work-Place Healthiness with the Probiotic Lactobacillus Reuteri: A Randomised, Double-Blind Placebo-Controlled Study. Environ Health, 4, 25.
28. Imase, K., et al. (2007) Lactobacillus Reuteri Tablets Suppress Helicobacter Pylori Infection: A Double-Blind, Randomised, Placebo-Controlled Crossover Clinical Study. Kansenshogaku Zasshi (Journal of the Japanese Association for Infectious Diseases, 81, 387-93.
29. Saggioro, A. (2005) Heliobacter Pylori Eradication with Lactobacillus Reuteri. A Double-Blind Placebo-Controlled Study. Digestive and Liver Diseases, 37, S88.
30. Niv, E., et al. (2005) The Efficacy of Lactobacillus Reuteri ATCC 55730 in the Treatment of Patients with Irritable Bowel Syndrome--a Double Blind, Placebo-Controlled, Randomized Study. Clin Nutr, 24, 925-31.
31. Ouwehand, A.C., et al. (2002) Effect of Probiotics on Constipation, Fecal Azoreductase Activity and Fecal Mucin Content in the Elderly. Ann Nutr Metab, 46, 159-62.
32. Krasse, P., et al. (2006) Decreased Gum Bleeding and Reduced Gingivitis by the Probiotic Lactobacillus Reuteri. Swed Dent J, 30, 55-60.
33. Caglar, E., et al. (2006) Salivary Mutans Streptococci and Lactobacilli Levels after Ingestion of the Probiotic Bacterium Lactobacillus Reuteri ATCC 55730 by Straws or Tablets. Acta Odontol Scand, 64, 314-8.
34. Nikawa, H., et al. (2004) Lactobacillus Reuteri in Bovine Milk Fermented Decreases the Oral Carriage of Mutans Streptococci. Int J Food Microbiol, 95, 219-23.
35. Wolf, B.W., et al. (1998) Safety and Tolerance of Lactobacillus Reuteri Supplementation to a Population Infected with the Human Immunodeficiency Virus. Food Chem Toxicol, 36, 1085-94.
36. Wolf, B.W., et al. (1995) Safety and Tolerance of Lactobaciullus Reuteri in Healthy Adult Subjects. Microbial Ecology in Health and Disease, 8, 41-50.
37. Dobrogosz, W.J. (2005) Enhancement of Human Health with Lactobacillus Reuteri a Probiotic, Immunobiotic and Immunoprobiotic. Nutrafoods, vol. 4, pp. 15-28.
38. Connolly, E. (2004) Lactobacillus Reuteri ATCC 55730 a Clinically Proven Probiotic. Nutrafoods, vol. 3, pp. 15-22.
39. Casas, I.A., et al. (2000) Validation of the Probiotic Concept: Lactobacillus Reuteri Confers Broad-Spectrum Protection against Disease in Humans and Animals. Microbial Ecology in Health and Disease, 12, 247-85.
40. Gibson, G.R., et al. (2005) An Evaluation of Probiotic Effects in the Human Gut: Microbial Aspects. Final Technical Report for Food Standards Agency (FSA) Project Ref G01022.
41. Elliott, E., et al. (2004) An Evaluation of Nine Probiotics Available in South Africa, August 2003. S Afr Med J, 94, 121-4.
42. Temmerman, R., et al. (2003) Identification and Antibiotic Susceptibility of Bacterial Isolates from Probiotic Products. Int J Food Microbiol, 81, 1-10.
43. Connolly, E. (2005) Lactobacillus Reuteri Drops Novel Delivery System. NutraFoods, vol. 4, pp. 65-8.
44. de Morais, M.B., et al. (2006) The Role of Probiotics and Prebiotics in Pediatric Practice. J Pediatr (Rio J), 82, S189-97.
45. Rosenfeldt, V., et al. (2002) Effect of Probiotic Lactobacillus Strains on Acute Diarrhea in a Cohort of Nonhospitalized Children Attending Day-Care Centers. Pediatr Infect Dis J, 21, 417-9.
46. Arunachalam, K., et al. (2000) Enhancement of Natural Immune Function by Dietary Consumption of Bifidobacterium Lactis (Hn019). Eur J Clin Nutr, 54, 263-7.
47. Pedone, C.A., et al. (2000) Multicentric Study of the Effect of Milk Fermented by Lactobacillus Casei on the Incidence of Diarrhoea. Int J Clin Pract, 54, 568-71.
48. Kalliomaki, M., et al. (2001) Probiotics in Primary Prevention of Atopic Disease: A Randomised Placebo-Controlled Trial. Lancet, 357, 1076-9.
49. Kalliomaki, M., et al. (2003) Probiotics and Prevention of Atopic Disease: 4-Year Follow-up of a Randomised Placebo-Controlled Trial. Lancet, 361, 1869-71.
50. Rautava, S., et al. (2002) Probiotics During Pregnancy and Breast-Feeding Might Confer Immunomodulatory Protection against Atopic Disease in the Infant. J Allergy Clin Immunol, 109, 119-21.
51. Ahuja, M.C., et al. (2002) Antibiotic Associated Diarrhoea: A Controlled Study Comparing Plain Antibiotic with Those Containing Protected Lactobacilli. J Indian Med Assoc, 100, 334-5.
52. Correa, N.B., et al. (2005) A Randomized Formula Controlled Trial of Bifidobacterium Lactis and Streptococcus Thermophilus for Prevention of Antibiotic-Associated Diarrhea in Infants. J Clin Gastroenterol, 39, 385-9.
53. Gaon, D., et al. (2003) Effect of Lactobacillus Strains and Saccharomyces Boulardii on Persistent Diarrhea in Children. Medicina (B Aires), 63, 293-8.
54. Kurugol, Z., et al. (2005) Effects of Saccharomyces Boulardii in Children with Acute Diarrhoea. Acta Paediatr, 94, 44-7.
55. Thibault, H., et al. (2004) Effects of Long-Term Consumption of a Fermented Infant Formula (with Bifidobacterium Breve C50 and Streptococcus Thermophilus 065) on Acute Diarrhea in Healthy Infants. J Pediatr Gastroenterol Nutr, 39, 147-52.

     
     
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
     
 
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